BPC-157 (Body Protection Compound)
A pentadecapeptide derived from human gastric juice, extensively studied for its tissue-healing, anti-inflammatory, and cytoprotective properties.
Mechanism of Action
BPC-157 upregulates growth factor expression (VEGF, EGF, FGF), promotes angiogenesis, modulates the NO system (both eNOS and iNOS), activates the FAK-paxillin signaling pathway for cell migration, and interacts with the dopaminergic system. It promotes tendon-to-bone healing, accelerates wound closure, and protects against NSAID-induced gastrointestinal damage.
Key Published Studies
Pentadecapeptide BPC 157 and Its Effects on a Gastrointestinal Tract Model of Injury and Healing
Seiwerth S, Brcic L, Vuletic LB, et al. — Current Pharmaceutical Design (2018)
BPC-157 demonstrated potent cytoprotective and healing effects across multiple GI injury models, including NSAID damage, alcohol lesions, and inflammatory bowel disease models.
Stable Gastric Pentadecapeptide BPC 157: Novel Therapy in Gastrointestinal Tract
Sikiric P, Seiwerth S, Rucman R, et al. — Current Pharmaceutical Design (2011)
BPC-157 accelerated healing of gastrointestinal fistulas, anastomoses, and short bowel syndrome in rat models with no observed toxicity even at very high doses.
BPC 157 and the Achilles Tendon
Krivic A, Anic T, Seiwerth S, et al. — Journal of Orthopaedic Surgery and Research (2006)
BPC-157 significantly accelerated Achilles tendon healing in a rat transection model, improving both biomechanical strength and histological organization.
Dosage Range
Subcutaneous research doses: 200-500 mcg/day in animal models. Some protocols use 10-20 mcg/kg body weight.
Reconstitution
Reconstitute with bacteriostatic water. For a 5 mg vial, add 2 mL BAC water for a 2.5 mg/mL solution.
Storage
Store lyophilized powder at -20C. Reconstituted solution at 2-8C, use within 21 days. Stable at room temperature short-term.
Half-Life
Approximately 4 hours after subcutaneous administration in animal models.
For Research Use Only. The information on this page is intended for educational and informational purposes only. It does not constitute medical advice, diagnosis, or treatment recommendations. All products sold by PrestigePeptides are strictly for laboratory research use and are not intended for human or veterinary consumption.
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