Semax
A synthetic heptapeptide analogue of ACTH(4-7) developed in Russia, studied for its neuroprotective, nootropic, and neurotrophic properties.
Mechanism of Action
Semax modulates BDNF (brain-derived neurotrophic factor) and NGF (nerve growth factor) expression in the hippocampus and cortex. It activates melanocortin receptors (MC3R/MC4R), modulates monoamine neurotransmitter levels (dopamine, serotonin, norepinephrine), inhibits enkephalin-degrading enzymes, and reduces oxidative stress in neural tissue. These combined actions underlie its neuroprotective and cognitive-enhancing properties.
Key Published Studies
Semax, an ACTH(4-10) Analogue with Nootropic Properties, Activates BDNF and trkB Gene Expression in the Rat Hippocampus
Dolotov OV, Karpenko EA, Inozemtseva LS, et al. — Brain Research (2006)
Semax administration significantly upregulated BDNF and TrkB receptor expression in rat hippocampus, suggesting a mechanism for its cognitive-enhancing effects.
Neuroprotective Effects of Semax in a Model of Incomplete Global Cerebral Ischemia in Rats
Bashkatova VG, Koshelev VB, Fadyukova OE, et al. — Neuroscience and Behavioral Physiology (2001)
Semax demonstrated significant neuroprotective effects in ischemic brain injury models, reducing neuronal death and improving functional recovery.
Genomic Effects of the Synthetic ACTH Analogue Semax on Rat Brain Transcriptome
Agapova TY, Agniullin YV, Silachev DN, et al. — Doklady Biological Sciences (2007)
Semax altered the expression of over 60 genes related to neuroprotection, immune modulation, and vascular function in the rat brain.
Dosage Range
Intranasal research protocols typically use 100-600 mcg/day. Subcutaneous research doses range from 100-500 mcg.
Reconstitution
Reconstitute lyophilized powder with bacteriostatic water. For a 10 mg vial, add 2 mL BAC water for a 5 mg/mL solution.
Storage
Store lyophilized powder at -20C. Reconstituted solution at 2-8C, use within 21 days.
Half-Life
Approximately 3-5 minutes in plasma; however, its neurotropic effects persist for 20-24 hours due to genomic-level activity.
For Research Use Only. The information on this page is intended for educational and informational purposes only. It does not constitute medical advice, diagnosis, or treatment recommendations. All products sold by PrestigePeptides are strictly for laboratory research use and are not intended for human or veterinary consumption.
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