Thymosin Alpha-1
A 28-amino-acid thymic peptide studied for its immunomodulatory properties, particularly T-cell maturation, dendritic cell activation, and antiviral responses.
Mechanism of Action
Thymosin alpha-1 activates toll-like receptors (TLR2, TLR9) on dendritic cells, promotes T-cell differentiation (CD4+ and CD8+), enhances NK cell activity, stimulates IL-2 and IFN-alpha production, and modulates the Th1/Th2 balance toward Th1 immunity. It also promotes thymic recovery in immunocompromised states.
Key Published Studies
Thymalfasin (Thymosin Alpha 1) in the Treatment of Chronic Hepatitis B
Andreone P, Cursaro C, Gramenzi A, et al. — Digestive and Liver Disease (2001)
Thymosin alpha-1 produced sustained virological response in chronic HBV patients through enhanced T-cell mediated immune clearance of infected hepatocytes.
Thymosin Alpha 1 as a Stimulant of Innate Immunity
Romani L, Bistoni F, Montagnoli C, et al. — Annals of the New York Academy of Sciences (2007)
Thymosin alpha-1 enhanced dendritic cell maturation, TLR signaling, and innate immune responses against both bacterial and fungal pathogens.
Dosage Range
Subcutaneous research doses: 0.8-6.4 mg twice weekly. Clinical doses have used 1.6 mg twice weekly.
Reconstitution
Reconstitute with bacteriostatic water. For a 5 mg vial, add 1 mL BAC water for 5 mg/mL.
Storage
Store lyophilized at -20C. Reconstituted at 2-8C, use within 14 days.
Half-Life
Approximately 2 hours after subcutaneous administration.
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For Research Use Only. The information on this page is intended for educational and informational purposes only. It does not constitute medical advice, diagnosis, or treatment recommendations. All products sold by PrestigePeptides are strictly for laboratory research use and are not intended for human or veterinary consumption.
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